Catalyst??Free N??Arylation Using Unactivated Fluorobenzenes

F Diness, DP Fairlie

文献索引：Diness, Frederik; Fairlie, David P. Angewandte Chemie - International Edition, 2012 , vol. 51, # 32 p. 8012 - 8016

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被引用次数: 53

摘要

N-arylation of heteroaromatic compounds is an extremely important CÀN bond-forming reaction in organic synthesis, especially with N-arylated azole and indole derivatives finding important uses (Scheme 1) as inhibitors of enzymes [1](eg COX-1,[1a] COX-2,[1b] PDE3,[1c] PDE5,[1d] topoisomerase II [1e]), inhibitors of ATP binding,[2] agonists or antagonists of G protein-coupled and other receptors [3](eg DA D-2,[3a] 5-HT2,[3b] α1AR,[3a] CB1,[3b, c] ...