Synthesis of febrifugine derivatives and development of an effective and safe tetrahydroquinazoline-type antimalarial

H Kikuchi, S Horoiwa, R Kasahara, N Hariguchi…

文献索引：Kikuchi, Haruhisa; Horoiwa, Seiko; Kasahara, Ryota; Hariguchi, Norimitsu; Matsumoto, Makoto; Oshima, Yoshiteru European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 10 - 19

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被引用次数: 16

摘要

Abstract Febrifugine, a quinazoline alkaloid isolated from Dichroa febrifuga roots, shows powerful antimalarial activity against Plasmodium falciparum. Although the use of ferifugine as an antimalarial drug has been precluded because of its severe side effects, its potent ...