Tetrahedron letters

NMR recognition studies of C· G base pairs by new easily accessible heterobicyclic systems

F Lecubin, R Benhida, JL Fourrey, JS Sun

文献索引：Lecubin, Florence; Benhida, Rachid; Fourrey, Jean-Louis; Sun, Jian-Sheng Tetrahedron Letters, 1999 , vol. 40, # 46 p. 8085 - 8088

全文：HTML全文

被引用次数: 10

摘要

Recognition of DNA duplexes by triplex forming oligonucleotides (TFO) is limited to DNA homopurine sequences. As a first step to overcome this limitation we report here NMR recognition studies of the C· G base pair by new heterocyclic systems, derived from benzimidazole and benzoxazole units bearing an urea donor moiety, designed to bound to the 4-amino group of the cytosine and the O4-and N7-atoms of the guanosine bases, ...