Rapid and Efficient Synthesis of Unsymmetrical Phosphinic Acids R′ P (O) OHR ″

…, E Guénin, J Hardouin, M Lecouvey

文献索引：Fougere, Cecile; Guenin, Erwann; Hardouin, Julie; Lecouvey, Marc European Journal of Organic Chemistry, 2009 , # 34 p. 6048 - 6054

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被引用次数: 13

摘要

Abstract A new synthesis of unsymmetrical phosphinic acids R′ P (O) OHR ″has been evaluated. The first P–C bond was formed by base-promoted H-phosphinate alkylation of a protected H-phosphinate, which is easier and safer to handle. A one-pot methodology was developed for the second P–C bond formation reaction that involves the sila-Arbuzov reaction. This methodology was then extended to the synthesis of a dialkylphosphinic acid ...