Synthesis of highly. mu. and. delta. opioid receptor-selective peptides containing a photoaffinity group

G Landis, G Lui, JE Shook, HI Yamamura…

文献索引：Landis; Lui; Shook; Yamamura; Burks; Hruby Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 638 - 643

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被引用次数: 18

摘要

A series of cyclic, conformationally constrained photolabile peptides related to the enkephalins and to somatostatin were designed and synthesized in an effort to develop highly selective and potent peptides for the 6 and p opioid receptors. The following new peptides were prepared and tested for their 6 opioid receptor potency and selectivity-in the guinea pig ileum assay, the mouse vas deferens assay, and the rat brain binding assay: H ...