Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1, 2-heteroannelated anthraquinones and anthra [1, 2-d] imidazole-6, 11-dione …

HS Huang, TC Chen, RH Chen, KF Huang…

文献索引：Huang, Hsu-Shan; Chen, Tsung-Chih; Chen, Ruei-Huei; Huang, Kuo-Feng; Huang, Fong-Chun; Jhan, Jing-Ru; Chen, Chun-Liang; Lee, Chia-Chung; Lo, Yang; Lin, Jing-Jer Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 21 p. 7418 - 7428

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被引用次数: 41

摘要

A series of 1, 2-heteroannelated anthraquinones and anthra [1, 2-d] imidazole-6, 11-dione tetracyclic analogues with different side chain were prepared using an various synthetic route via acylation, cyclization, condensation, and intramolecular heterocyclization. Tetracyclic system containing alkyl and aryl, aromatic and heterocyclic, linear and cyclic, polar and apolar, and basic and acids residues were incorporated. They were evaluated ...