Tetrahedron

Synthesis of the pentacyclic intermediate for dynemicin a and unusual formation of spiro-oxindole ring

T Okita, M Isobe

文献索引：Okita, Takaaki; Isobe, Minoru Tetrahedron, 1994 , vol. 50, # 38 p. 11143 - 11152

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被引用次数: 106

摘要

A pentacyclic compound was synthesized as an important intermediate of antitumor antibiotic dynemicins. The key step was the intramolecular Heck reaction using catalytic Pd reagent. During the course of the synthetic studies, an unusual spiro ring compound was found to be produced via intramolecular conjugate addition.