Convenient and Efficient Syntheses of N 6-and N 4-Substituted Adenines and Cytosines and their 2′-Deoxyribosides

…, J Barciszewski, WT Markiewicz

文献索引：Adamska, Ewelina; Barciszewski, Jan; Markiewicz, Wojciech T. Nucleosides, Nucleotides and Nucleic Acids, 2012 , vol. 31, # 12 p. 861 - 871

全文：HTML全文

被引用次数: 4

摘要

Convenient and efficient methods of the synthesis of N6-and N4-substituted derivatives of adenine and cytosine and their 2′-deoxyribosides were developed. The reactions of either unprotected nucleobases (adenine, cytosine) or unprotected 2′-deoxyribosides with aryl or alkyl aldehydes give corresponding Schiff bases that can be reduced to the target title compounds with high overall yields. In the case of aryl aldehydes the imine derivatives are ...