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2-Aryl-5-benzoxazolealkanoic acid derivatives with notable antiinflammatory activity

DW Dunwell, D Evans, TA Hicks…

文献索引:Dunwell,D.W. et al. Journal of Medicinal Chemistry, 1975 , vol. 18, # 1 p. 53 - 58

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被引用次数: 63

摘要

The synthesis and antiinflammatory activity of 5-substituted 2-arylbenzoxazoles are described. Initial screening on carrageenin-induced rat paw edema showed that cu- methylacetic substitution in the 5 position was preferable to substitutions with the equivalent esters, amides, alcohols, amines, or tetrazoles. Halogen substitution in the aryl ring led to the most active compounds which were 2-(4-chlorophenyl)-~-methyl-5-benzoxazoleacetic ...

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