Synthesis, analgesic and anti-inflammatory activities of some novel 2, 3-disubstituted quinazolin-4 (3H)-ones.

…, N Pavalarani, P Vasanthanathan, R Revathi

文献索引：Alagarsamy, Veerachamy; Muthukumar, Veluchamy; Pavalarani, Nagendran; Vasanthanathan, Poongavanam; Revathi, Rajappan Biological and pharmaceutical bulletin, 2003 , vol. 26, # 4 p. 557 - 559

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被引用次数: 83

摘要

A series of novel 2-benzylamino-3-substituted quinazolin-4 (3H)-ones have been synthesized by treating 3-amino-2-benzylamino quinazolin-4 (3H)-one, with different aldehydes and ketones. The starting material 3-amino-2-benzylamino quinazolin-4 (3H)-one was synthesized by nucleophilic substitution of thiomethyl group of 3-amino-2-methylthio quinazolin-4 (3H)-one by benzylamine. The title compounds were investigated for ...