A new cyclic acetal (1) of marmin (6′, 7′-dihydroxy-7-geranyloxycoumarin), two new cyclic acetals (5, 6) of 6′, 7′-dihydroxybergamottin, and the known compounds marmin (2), 7- geranyloxycoumarin (3), bergamottin (4), and 6′, 7′-dihydroxybergamottin (7) were isolated from grapefruit peel oil. All compounds were tested for inhibitory activity against intestinal cytochrome P450 3A4, an enzyme involved in the “grapefruit/drug” interactions ...
[Bellevue III, Frank H.; Woster, Patrick M.; Edwards, David J.; He, Kan; Hollenberg, Paul F. Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 20 p. 2593 - 2598]
