Towards cytotoxic and selective derivatives of maslinic acid

B Siewert, E Pianowski, A Obernauer, R Csuk

文献索引：Siewert, Bianka; Pianowski, Elke; Obernauer, Anja; Csuk, Rene Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 594 - 615

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被引用次数: 36

摘要

Abstract Several novel esters and amides of maslinic acid were prepared. Their evaluation for cytotoxic activity with a panel of human cancer cell lines using a sulforhodamine B (SRB) assay revealed for some of them a noteworthy activity. The results from annexinV-FITC and caspase-assays as well as from DNA laddering experiments provided evidence for an apoptotic cell death. A diacetylated benzylamide (15) induced a G1/G0 arrest in tumor ...