Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in …

…, RF Bousley, KL Hamelehle, R Homan…

文献索引：Lee, Helen T.; Sliskovic, Drago R.; Picard, Joseph A.; Roth, Bruce D.; Wierenga, Wendell; Hicks, James L.; Bousley, Richard F.; Hamelehle, Katherine L.; Homan, Reynold; Speyer, Cecilia; Stanfield, Richard L.; Krause, Brian R. Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5031 - 5034

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被引用次数: 85

摘要

S0022-2623 (96) 00674-7 CCC: $12.00© 1996 American Chemical Society through the membrane and not the aqueous volume surrounding the membrane. 6 Thus, activity of a membrane-bound inhibitor should depend on both the total inhibitor concentration and the amount of membrane available for inhibitor adsorption. The amount of inhibitor bound to the membrane can be determined at various membrane concentrations from a single ...