An Approach to Model the Active Site of Peptidglycine?螃窿?hydroxylating monooxygenase (PHM)

T Hoppe, P Josephs, N Kempf, C Wölper…

文献索引：Hoppe, Tobias; Josephs, Patrick; Kempf, Natascha; Woelper, Christoph; Schindler, Siegfried; Neuba, Adam; Henkel, Gerald Zeitschrift fur Anorganische und Allgemeine Chemie, 2013 , vol. 639, # 8-9 p. 1504 - 1511

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被引用次数: 6

摘要

Abstract The copper (I) and copper (II) complexes [Cu ((TMG et) 2 N et SEt)] BPh 4 (1· BPh 4) and [Cu ((TMG et) 2 N et SEt) Cl] Cl (2· Cl) with (TMG et) 2 N et SEt=((Me 2 N) 2 C= NCH 2 CH 2) 2 NCH 2 CH 2 SEt were synthesized and structurally characterized as a model system for the copper enzyme PHM, a monooxygenase involved in the activation of peptide hormones and neuropeptides. The reaction of the copper (I) complex 1· BPh 4 with ...