I $!? R= F to abolish efficacy but not the affinity for 5-HTlA receptors. 12 Thus,(S)-5-fluoro-8- hydroxy-2-(dipropylamino)-tetralin [(S)-2] behaves as a 5-HTlA-receptor antagonist. This conclusion is corroborated by the ability of (8-2 to inhibit (R)-1-induced biochemical and behavioral changes in the rat in a dose-dependent manner. In contrast, racemic 2 is inactive in functional assays and (R)-2, although being of slightly lower potency than (R)-and (9-1, ...
