Tetrahedron letters

Chiral acetylenic sulfoxides in organic synthesis: Secondary amine cyclization and total synthesis of (S)-(−)-carnegine

W Chan, AWM Lee, L Jiang

文献索引：Chan, Winghong; Lee, Albert W. M.; Jiang, Lasheng Tetrahedron Letters, 1995 , vol. 36, # 5 p. 715 - 718

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被引用次数: 26

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Michael addition of secondary amines 1b–1g onto chiral acetylenic sulfoxides 2 followed by acid induced cyclization afforded structures of tetrahydroisoquinoline skeleton in high to moderate diastereoselectivity. Optical pure (S)-(−)-carnegine has been synthesized.