4, 5-Disubstituted-3 (2H)-pyridazinones were initially synthesized via sodium alkoxide additions to an advanced bromide intermediate. A small parallel chemistry effort resulted in a poor success rate, and we thus increased the reactivity of the reaction partner by performing a copper-catalyzed Finkelstein reaction. Copper-catalyzed coupling of a diverse set of alcohols with the resulting iodide resulted in a more successful effort. A number of ...