Tetrahedron letters

Design, synthesis and biological evaluation of new oxazines with potential antiparasitic activity

D Gamenara, H Heinzen, P Moyna

文献索引：Gamenara, Daniela; Heinzen, Horacio; Moyna, Patrick Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2505 - 2507

全文：HTML全文

被引用次数: 15

摘要

A series of new oxazines with potential antiparasitic activity was prepared using Diels–Alder reactions, based on terpenes derived from eucarvone as dienes and nitrosoarenes with different electronic characteristics as dienophiles. The biological activity was evaluated with in vitro assays against Plasmodium falciparum, Trypanosoma cruzi and Trypanosoma brucei rhodesiense. Some of these oxazines have activities in the 20–50μM range, and may be ...