Transformation of thiols to disulfides by epolactaene and its derivatives

K Kuramochi, T Sunoki, K Tsubaki, Y Mizushina…

文献索引：Kuramochi, Kouji; Sunoki, Takashi; Tsubaki, Kazunori; Mizushina, Yoshiyuki; Sakaguchi, Kengo; Sugawara, Fumio; Ikekita, Masahiko; Kobayashi, Susumu Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4162 - 4172

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被引用次数: 5

摘要

Abstract In this paper we report a disulfide formation of thiols induced by epolactaene and its derivatives. We previously reported the disulfide formation of N-acetylcysteine methyl ester by epolactaene in a 1: 1 MeOH/0.5 M NaHCO 3 aq solution. The present studies reveal that the disulfide formation proceeds under mild conditions such as in PBS at pH 7.3, suggesting that epolactaene may induce disulfide formation of cellular thiols. This compound induces ...