SAR studies on a novel series of human cytomegalovirus primase inhibitors

X Chen, J Adrian, T Cushing, H DiMaio, L Liang…

文献索引：Chen; Adrian; Cushing; DiMaio; Liang; Mayorga; Miao; Peterson; Powers; Spector; Stein; Wright; Xu; Ye; Jaen Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2188 - 2192

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被引用次数: 12

摘要

A novel series of imidazolylpyrimidines were found to possess inhibitory activity against the human CMV UL70 primase. Extensive SAR studies on an HTS lead led to potent, orally bioavailable compounds with anti-CMV IC50 values of 150nM in both viral yield and viral DNA replication assays and with a much reduced cytotoxicity compared to marketed treatments ganciclovir and cidofovir.