Tetrahedron Letters

One-pot synthesis of organophosphate monoesters from alcohols

LM Lira, D Vasilev, RA Pilli, LA Wessjohann

文献索引：Lira, Lucas M.; Vasilev, Dimitar; Pilli, Ronaldo A.; Wessjohann, Ludger A. Tetrahedron Letters, 2013 , vol. 54, # 13 p. 1690 - 1692

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被引用次数: 5

摘要

A one-pot procedure for the phosphorylation of alcohols provides the corresponding phosphate monoesters in improved yields. The protocol features the use of tetrabutylammonium hydrogen phosphate and trichloroacetonitrile, followed by purification of the crude product by flash chromatography on silica gel. The final step, cation exchange chromatography, affords the organophosphates as ammonium salts that are usually ...