Journal of medicinal chemistry

Synthesis and antidepressant profiles of phenyl-substituted 2-amino-and 2-[(alkoxycarbonyl) amino]-1, 4, 5, 6-tetrahydropyrimidines

K Weinhardt, MB Wallach, M Marx

文献索引：Weinhardt, Klaus; Wallach, Marshall B.; Marx, Michael Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 694 - 698

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被引用次数: 29

摘要

A series of 4 (6)-and 5-phenyl-substituted 2-amino-and 2-[(alkoxycarbonyl) amino]-1, 4, 5, 6- tetrahydropyrimidines 2 were prepared and evaluated for central nervous system (CNS) effects in animal models. Several 5-phenyl-substituted compounds possessed potent antidepressant activity and all compounds in this series were devoid of significant activity in any of the other CNS (anticonvulsant, muscle relaxant, and depressant) assays. The most ...