Reactions of furocoumarins. II. Synthetic aminomethyl psoralens via chloromethylation or benzylic bromination

KD Kaufman, DJ Erb, TM Blok…

文献索引：Kaufman; Erb; Blok; et al. Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 5 p. 1051 - 1056

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被引用次数: 18

摘要

Abstract Several psoralen derivatives have been synthesized in order to evaluate their efficacy as photochemotherapeutic (PUVA) agents, including a variety of 4′-substituted-4, 5′, 8-trimethypsoralen compounds (1d-j). Improved synthesis of the very potent photosensitizers 8-methylpsoralen (6a) and 4, 8-dimethylpsoralen (6b) are described and 6a has been shown to undergo formylation in the 4′-position. Free radical bromination of ...