Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase

…, SA Staley, RJ Brideau, SJ Conrad, ML Knechtel…

文献索引：Vaillancourt, Valerie A; Cudahy, Michele M.; Staley, Sandra A.; Brideau, Roger J.; Conrad, Steven J.; Knechtel, Mary L.; Oien, Nancee L.; Wieber, Janet L.; Yagi, Yoshihiko; Wathen, Michael W. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 18 p. 2079 - 2081

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被引用次数: 41

摘要

ortho-Hydroxynaphthalene carboxamides have been identified as inhibitors of HCMV DNA polymerase. SAR investigations have demonstrated that both the amide and hydroxy functionalities are required for activity. Substitution on the naphthalene ring has led to inhibitors with submicromolar IC50s against HCMV polymerase. These compounds have been found to be> 100-fold selective for inhibition of HCMV polymerase versus human ...