Intramolecular Hydrogen Bonding in Derivatives of. beta.-Alanine and. gamma.-Amino Butyric Acid; Model Studies for the Folding of Unnatural Polypeptide Backbones

GP Dado, SH Gellman

文献索引：Dado; Gellman Journal of the American Chemical Society, 1994 , vol. 116, # 3 p. 1054 - 1062

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被引用次数: 251

摘要

Abstract: We have examined the intramolecular hydrogen bonding behavior of simple 0-and y-amino acid derivatives as a prelude to efforts to design unnatural polyamides that will adopt compact and specific folding patterns analogous to those of a-amino acid polymers (proteins). We postulate that the desired folding behavior will be most likely if intramolecular hydrogen bonds are unfavorable between nearest neighbor amide groups on the polymer ...