Structure-activity relationships of 2-(benzothiazolylthio) acetamide class of CCR3 selective antagonist

…, K Kobayashi, M Ishikawa, K Ohwaki, T Saeki…

文献索引：Naya, Akira; Kobayashi, Kensuke; Ishikawa, Makoto; Ohwaki, Kenji; Saeki, Toshihiko; Noguchi, Kazuhito; Ohtake, Norikazu Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 6 p. 697 - 701

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被引用次数: 39

摘要

The structure activity relationships of novel selective CCR3 receptor antagonists, 2- (benzothiazolylthio) acetamimde derivatives were described. A lead structure (1a) was discovered from the screening of the focused library that was based on the structure of our dual antagonists for the human CCR1 and CCR3 receptors. Derivatization of 1a including incorporation of substituent (s) into each benzene ring of the benzothiazole and piperidine ...