Ion channel topography of the neuronal nicotinic acetylcholine receptor: Pharmacochemical approaches

…, NB Brovtsyna, SE Serdyuk, NY Lukomskaya

文献索引：Gmiro; Brovtsyna; Serdyuk; Lukomskaya Russian Journal of Bioorganic Chemistry, 2002 , vol. 28, # 2 p. 116 - 127

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被引用次数: 2

摘要

Abstract Forty-three bisammonium ganglionic blockers were synthesized to study the structure of the ion channel of nicotinic acetylcholine receptor. The conformational parameters of these blockers were studied, and their effects toward the ganglionic transmission in situ on the sympathetic feline superior cervical ganglia and in vitro on the parasympathetic guinea-pig small intestine ganglia were determined. A model of the ...