The copper-catalyzed N-arylation of indoles

JC Antilla, A Klapars, SL Buchwald

文献索引：Antilla, Jon C.; Klapars, Artis; Buchwald, Stephen L. Journal of the American Chemical Society, 2002 , vol. 124, # 39 p. 11684 - 11688

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被引用次数: 506

摘要

A general method for the N-arylation of indoles using catalysts derived from CuI and trans-1, 2-cyclohexanediamine (1a), trans-N, N'-dimethyl-1, 2-cyclohexanediamine (2a), or N, N'- dimethyl-ethylenediamine (3) is reported. N-Arylindoles can be produced in high yield from the coupling of an aryl iodide or aryl bromide with a variety of indoles.