Journal of medicinal chemistry

Synthesis of N, N-Bis (2-haloethyl) Aliphatic Amides

CH Gaozza

文献索引：Gaozza,C.H. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 400 - 401

全文：HTML全文

被引用次数: 10

摘要

1y during ttie hydrolysis of p-1- j the reutioii inistiire was proc.esed ... Synthesis of N,N-Bis(2-haloethyl ) Aliphatic A m ides ... Experimental N,N-Bis( 2-ch1oroethyl)amides.- -The arid chloride (0.04 nicilt~ j in dry chloroform was added slo~\-ly lo a stirred solution of bis- (2-chloroeth!-l)amine prepared froni t,he hydrochloride (0.045 mole) and pyridine (0.05 mole) in 1~1ili)roform. $tiiring xis con- iinued for 1 hr. and the mixture the11 TV ~ Y poured into water. Distillation of t,he ...