Development of a second-generation, highly efficient manufacturing route for the HIV integrase inhibitor raltegravir potassium

GR Humphrey, PJ Pye, YL Zhong…

文献索引：Organic Process Research and Development, , vol. 15, # 1 p. 73 - 83

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被引用次数: 22

摘要

... methylation, 3−4-fold higher productivity, and a 65% reduction of combined organic and aqueous ... First-Generation Process for the Synthesis of 1 To address the aforementioned chemical and ... 11) Due to the minimal impact on overall yield and ease of processing, the Michael ...