Design, synthesis and in vitro antitumour activity of new heteroaryl ethylenes

…, S Failla, A Trovato-Salinaro, G Musumarra

文献索引：Fortuna, Cosimo G.; Barresi, Vincenza; Bonaccorso, Carmela; Consiglio, Giuseppe; Failla, Salvatore; Trovato-Salinaro, Angela; Musumarra, Giuseppe European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 221 - 227

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被引用次数: 27

摘要

Almond and VolSurf+ modelling procedures allowed the structural design of new di-and mono-heteroaryl-ethylenes. The structural modifications suggested by the molecular modelling were verified by the synthesis of the designed molecules and by the evaluation of their in vitro activities against two lung tumour cell lines, A549 and H226. 2-{(E)-2-[5′- (Dibutylamino)-2, 2′-bithien-5-yl] vinyl}-1-methylquinolinium iodide exhibited in vitro ...