Chemistry of trichlorosilyl enolates. 1. New reagents for catalytic, asymmetric aldol additions

SE Denmark, SBD Winter, X Su…

文献索引：Denmark, Scott E.; Winter, Stephen B. D.; Su, Xiping; Wong, Ken-Tsung Journal of the American Chemical Society, 1996 , vol. 118, # 31 p. 7404 - 7405

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被引用次数: 167

摘要

The asymmetric aldol addition is among the most powerful reactions in synthetic organic chemistry and has been extensively studied over the past 15 years. 1 The strategies for reagentcontrolled asymmetric induction fall into three broadly defined classes (Chart 1):(1) asymmetric modification of the enolate with chiral acyl auxiliaries (A),(2) asymmetric modification of the enolate with chiral metalloid auxiliaries (B), and (3) asymmetric ...