A series of C-terminal amino alcohol dipeptide Aβ inhibitors

…, B Folmer, EG Goldbach, AC Guinn, LH Latimer…

文献索引：Garofalo, Albert W.; Wone, David W.G.; Phuc, Angela; Audia, James E.; Bales, Cheryl A.; Dovey, Harry F.; Dressen, Darren B.; Folmer, Beverly; Goldbach, Erich G.; Guinn, Ashley C.; Latimer, Lee H.; Mabry, Thomas E.; Nissen, Jeffrey S.; Pleiss, Michael A.; Sohn, Stephen; Thorsett, Eugene D.; Tung, Jay S.; Wu, Jing Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3051 - 3053

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被引用次数: 16

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Potent, small molecule Aβ inhibitors have been prepared that incorporate an alanine core bracketed by an N-terminal arylacetyl group and various C-terminal amino alcohols. The compounds exhibit stereospecific inhibition as demonstrated in an in vitro assay.