Journal of medicinal chemistry

Potential Antiradiation Drugs. III. 1 2-Amino-2-alkyl-1, 3-propanedithiols and 3-Amino-4-mercapto-1-butanol2

GR Handrick, ER Atkinson

文献索引：Handrick,G.R.; Atkinson,E.R. Journal of Medicinal Chemistry, 1966 , vol. 9, p. 558 - 562

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被引用次数: 14

摘要

R= CH3, CzHj workers' was appropriately modified by the use of the tosyl protective group on nitrogenS8 The tritosyl compound 2 was obtained in GO-707, yields by tosylation of 1 in pyridine or mixtures of pyridine and halogenated solvents. Conversion to the bisthiolacetate 3 and to tho K-tosyldithiol 4 also proceeded in high yield. The use of aqueous HC1 for the hydrolysis of 3 to 4 gave unsatisfactory results, the only identifiable product being p- ...