The Journal of Organic Chemistry

Ambident behavior of ketone enolate anions in SNAr substitutions on fluorobenzonitrile substrates

NE Guedira, R Beugelmans

文献索引：Guedira, Nour-Eddine; Beugelmans, Rene Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5577 - 5585

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被引用次数: 5

摘要

2, 6-Difluorobenzonitrile was found to be a suitable substrate for studying carbon versus oxygen nucleophilic attack by enolate anions of weakly acidic ketones. The influence of the nucleophile structure and the solvent are investigated. The charge control character of the reaction and the influence of the substrate are discussed.