Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity

RRL Hamer, JJ Tegeler, ES Kurtz…

文献索引：Journal of Medicinal Chemistry, , vol. 39, # 1 p. 246 - 252

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被引用次数: 33

摘要

... Journal of Medicinal Chemistry. ... Corey's early discovery that arachidonate hydroxamic acid inhibits 5-LO in vitro 9 sparked a flurry of medicinal research toward specific 5-LO inhibitors with antiinflammatory activity. ...