Among the natural products of the type-II polyketide biosynthesis,[1] highly oxidized polycyclic structures, such as auxarthrol B (1)[2] and tetracenomycin C (2),[3] are attractive for their biological relevance as well as for synthetic challenges (Scheme 1). In our continuing synthetic studies on the exploitation of isoxazole-based intermediates like A,[4] we have addressed the issue of installing the “angular cisdiols” that are characteristic of ...
