Synthetic Communications

Synthesis of Chiral NADH Analog Based on Proline Template Including Thiourea and Nicotinic Acid Moieties

G Bagdžiūnas, M Haukka, E Butkus

文献索引：Bagdziunas, Gintautas; Haukka, Matti; Butkus, Eugenijus Synthetic Communications, 2011 , vol. 41, # 17 p. 2517 - 2523

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被引用次数: 1

摘要

Abstract Chiral reductase-mimicking organic molecule built on proline template incorporating a covalently bound NADH mimic via thiourea, and related reducing agent Hantzsch dihydropyridine, was designed. A synthetic path was developed involving interlinking of chiral proline derivatives with thiourea and subsequent coupling reaction with nicotinoyl chloride. The structure of target compound was studied by x–ray, indicating a ...