Abstract: Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles. ... Keywords: Cyclizations, combinatorial chemistry, 1,2,4-triazoles, Pinner reaction, hydrazides, imidates. ... Substituted 1,2,4-triazoles [1] have become very important in medicinal chemistry due to their ability to display a high ...
