Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or …

…, MA Winter, KS Hirsch, N Stamm…

文献索引：Jones, C. David; Winter, Mark A.; Hirsch, Kenneth S.; Stamm, Nancy; Taylor, Harold M.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 416 - 429

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被引用次数: 62

摘要

The preparation and in vitro aromatase inhibitory activity of a wide variety of heterocyclic (4, 4'-dichlorodipheny1) methanes and-methanoh are described. The choice of the two diaryl- bearing moieties as a vehicle for the evaluation of the heterocycles was made by the comparison of series of imidazole and pyridine-derived compounds with similar pyrimidine compounds reported previously. A structural model for the most active compounds is also ...