Solvent-free synthesis of 3, 5-di (hetero) aryl-1, 2, 4-thiadiazoles by grinding of thioamides under oxidative conditions

…, J Chen, W Gao, H Jin, J Ding, H Wu

文献索引：Xu, Yali; Chen, Jiuxi; Gao, Wenxia; Jin, Huile; Ding, Jinchang; Wu, Huayue Journal of Chemical Research, 2010 , # 3 p. 151 - 153

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被引用次数: 8

摘要

An efficient and facile synthesis of 3, 5-di (hetero) aryl-1, 2, 4-thiadiazoles by oxidative dimerisation of thioamides by grinding with NBS under solvent-free conditions at room temperature has been developed. The efficiency of this reaction was demonstrated by the compatibility with trifluoromethyl, methyl, methoxy, chloro, pyridyl and thienyl groups. This method has notable advantages in terms of short reaction times, high yields and is a more ...