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Synthesis of Aryl Thioethers through the N-Chlorosuccinimide-Promoted Cross-Coupling Reaction of Thiols with Grignard Reagents

JH Cheng, C Ramesh, HL Kao, YJ Wang…

文献索引:Cheng, Jun-Hao; Ramesh, Chintakunta; Kao, Hsin-Lun; Wang, Yu-Jen; Chan, Chien-Ching; Lee, Chin-Fa Journal of Organic Chemistry, 2012 , vol. 77, # 22 p. 10369 - 10374

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被引用次数: 43

摘要

A convenient one-pot approach for the synthesis of aryl sulfides through the coupling of thiols with Grignard reagents in the presence of N-chlorosuccinimide is described. The sulfenylchlorides were formed when thiols were treated with N-chlorosuccinimide, and the resulting sulfenylchlorides were then directly reacted with Grignard reagents to provide aryl sulfides in good to excellent yields under mild reaction conditions. Functional groups ...

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