Synthesis and biological activity of certain 6-substituted and 2, 6-disubstituted 2'-deoxytubercidins prepared via the stereospecific sodium salt glycosylation procedure

…, Z Kazimierczuk, S Geary, PA McKernan…

文献索引：Cottam, Howard B.; Kazimierczuk, Zygmunt; Geary, Stewart; McKernan, Patricia A.; Revankar, Ganapathi R.; Robins, Roland K. Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1461 - 1467

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被引用次数: 39

摘要

0022-2623/85/1828-1461 $01.50/0 by purine nucleoside phosphorylase. 1 These observations provide a good rationale for the synthesis of halogensubstituted 2'- deoxytubercidins as potential chemotherapeutic agents. Moreover, 5-iodotubercidin (2d) has been found to be a potent inhibitor of adenosine kinase.” 5-Iodo-5'-deoxytubercidin, which has recently been isolated from an extract of the marine red alga Hypnea valendiae ...