Highly direct, modular syntheses of several natural 8, 4'-oxyneolignans [(-)-1,(+)-1,(-)-2, and (-)-3] and some related variants [(-)-26,(+)-26,(+)-27, and (-)-28] are reported. Utilizing (S)-or (R)-methyl lactate as the chiral sources, two complementary syn-or anti-oriented routes were designed, encompassing nine and five steps, which were carried out to deliver the targets in an enantiomerically pure form. The embodiment of the two independent aryl and aryloxy ...
