13C kinetic isotope effects and the mechanism of the uncatalyzed decarboxylation of orotic acid
…, SR Merrigan, BJ Kim, P Beak, LM Phillips…
文献索引：Singleton, Daniel A.; Merrigan, Steven R.; Kim, Bong J.; Beak, Peter; Phillips, Linda M.; Lee, Jeehiun K. Journal of the American Chemical Society, 2000 , vol. 122, # 14 p. 3296 - 3300
A complete set of 13C kinetic isotope effects were determined for the thermal decarboxylation of 1, 3-dimethylorotic acid and compared with theoretically predicted isotope effects for decarboxylation via either O-2 or O-4 protonated pathways. The best correspondence of experimental and calculated isotope effects is found for the O-4 protonated mechanism. This observation and the calculated reaction barriers support the ...
