Synthesis of huperzine A, its analogs, and their anticholinesterase activity

…, Y Xia, ER Reddy, W Tuckmantel, I Hanin…

文献索引：Kozikowski; Xia; Reddy; Tuckmantel; Hanin; Tang Journal of Organic Chemistry, 1991 ,  vol. 56,  # 15  p. 4636 - 4645

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被引用次数: 111

摘要

Huperzine A is a new alkaloid isolated from the club moss Huperzia serrata (Thunb.) Trev., a Chinese folk medicine. This alkaloid exhibits potent activity as an inhibitor of acetylcholineaterase. Consequently, the compound is presently being investigated in China for the treatment of individuals suffering from various forms of memory impairment including Alzheimer's dementia. Details of the total synthesis of (f)-hupenine A are described as well ...