Synthesis and hydrogenation of (E)-γ-aryl-γ-morpholino-α-trifluoromethylated allyl alcohols through the reaction of trifluoroacetaldehyde ethyl hemiacetal with …
K Funabiki, Y Murase, Y Furuno, Y Kubota, M Ebihara…
Treatment of trifluoroacetaldehyde ethyl hemiacetal with enamines, derived from acetophenone derivatives, at room temperature gave (E)-1, 1, 1-trifluoro-4-morpholino-4-aryl- but-3-en-2-ols, which are intermediates for preparation of the β-trifluoromethylated aldol products, 4, 4, 4-trifluoro-3-hydroxy-1-aryl-butan-1-ones. The structure of the intermediate (E)-1, 1, 1-trifluoro-4-morpholino-4-(4-nitrophenyl)-but-3-en-2-ols could be assigned by ...
