Preparation of 2'-O-(. beta.-Cyanoethyl phosphoramidites) of 3'-Deoxycytidine and 3'-Deoxyguanosine and Their Use for Solid-Phase Synthesis of …

TL Sheppard, AT Rosenblatt…

文献索引：Sheppard, Terry L.; Rosenblatt, Andrew T.; Breslow, Ronald Journal of Organic Chemistry, 1994 ,  vol. 59,  # 24  p. 7243 - 7248

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被引用次数: 32

摘要

1. Access to derivatives of 3'-deoxyguanosine was provided by selective removal of the 3'- hydroxyl of guanosine (10). Thus, the 3'-0-thiocarbamate of 5'-O-(dimethoxytrityl)-2-N- (dimethylformamidyl)-2'-O-(triisopropylsilyl) guanosine (12) was reduced with tributyltin hydride and converted to phosphoramidite 2. In results to be reported elsewhere, phosphoramidites 1 and 2 were used to prepare oligodeoxynucleotides containing novel ...