The Journal of Organic Chemistry

Electrophilic sulfur transfer reactions in organic synthesis. Preparation of a diastereomer of the key macrocyclic component of griseoviridin

L Liu, RS Tanke, MJ Miller

文献索引：Liu, Li; Tanke, Robin S.; Miller, Marvin J. Journal of Organic Chemistry, 1986 ,  vol. 51,  # 26  p. 5332 - 5337

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被引用次数: 48

摘要

The utility of electrophilic sulfur transfer reactions was demonstrated by the synthesis of a diastereomer of the key macrocyclic cysteine containing component of griseoviridin. The key step involved direct reaction at the sulfur of N-(carbobenzyloxy)-S-phthalimido-L-cysteine tert-butyl ester with the anion derived from methyl 3-oxa-5 (S)-[(tert-butyldimethylsilyl) oxy] hexanoate.