Synthesis and structure-activity relationship of 1-aryl-6, 8-difluoroquinolone antibacterial agents
…, RE Maleczka Jr, CW Nordeen, AG Pernet
文献索引：Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Maleczka, Robert E.; Nordeen, Carl W.; Pernet, Andre G. Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 504 - 509
A series of new arylfluoroquinolones has been prepared. These derivatives are characterized by having fluorine atoms at the 6-and 8-positions, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position. The in vitro antibacterial potency is greatest when the 1-substituent is 2, 4-difluorophenyl and the 7-substituent is a 3- amino-1-pyrrolidinyl group. l-(4-Fluorophenyl)-6, 8-difluoro-7-piperazin-l-yl-l, 4-dihydro-4- ...
